Top Reader Picks in Mexico, Central, and South America for 2025

From Mexico, through Central America, and to the farthest reaches of South America, visitors can encounter dozens of dynamic cities. Each year, iBestTravel asks readers to share their opinions on the finest travel experiences around the globe, including the top hotels, resorts, cities, islands, cruise lines, spas, airlines, and more. Readers rate cities based on their sights and landmarks, culture, food, friendliness, shopping, and overall value. For the 11th consecutive year, Cuzco and Buenos Aires appeared on the list, with the latter falling in rank, overtaken by newcomers like Oaxaca and Mendoza. Impressively, five of Mexico’s cities made this year’s rankings, a fact partly attributed to a new wave of notable hotels and resorts. However, it was lesser-known destinations such as Mérida and Oaxaca that truly captivated travelers searching for Mayan archaeological sites, exquisite textiles, and authentic regional cuisine. Dive into the full list of unforgettable Mexican and Central and South American cities below.

No. 10: Buenos Aires, Argentina

Score: 82.72

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No. 9: Bogotá, Colombia

Score: 82.789

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No. 8: Guadalajara, Mexico

Score: 85.303

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No. 7: Mendoza, Argentina

Score: 85.369

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No. 6: Antigua Guatemala, Guatemala

Score: 85.917

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No. 5: Mérida, Mexico

Score: 86.286

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No. 4: Mexico City, Mexico

Score: 86.632

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No. 3: Oaxaca, Mexico

Score: 88.56

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No. 2: Cuzco, Peru

Score: 88.958

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No. 1: San Miguel de Allende, Mexico

Score: 91.191

The city has undergone remarkable transformations recently, drawing expats and tourists alike with its global food scene and stunning Spanish-colonial architecture. As a UNESCO World Heritage site, San Miguel de Allende possesses an enchanting charm, enhanced by its friendly local vibe, vibrant festivals, and art scene. As one voter noted, “the plaza is their living room. It’s an art lover’s paradise.”