Top 10 Reader-Recommended Cities in Mexico, Central & South America (2025)

Readers’ Favorite Cities in Central and South America

iBestTravel readers’ passion for traveling to countries throughout Central and South America remains strong. Winning cities are found in places like Colombia and Peru. Notably, half of this year’s top urban centers are located in one country alone—Mexico—demonstrating that our readers love to explore these vibrant destinations.

World’s Best Awards Survey Highlights

Every year, iBestTravel prompts readers to share their travel experiences globally, evaluating cities based on sights, landmarks, culture, cuisine, friendliness, shopping, and overall value. This year, San Miguel de Allende, with its manicured gardens, colonial architecture, and vibrant arts scene, captivated voters, securing the No. 1 slot not only in this regional category but also overall in our World’s Best Cities list. A reader remarked, “San Miguel is Mexico’s reward to those who wander into the interior highlands. The city has a new cosmopolitan feel that certainly feels welcoming to everyone.”

Top City Rankings

1. San Miguel de Allende

San Miguel de Allende stands out for its stunning gardens, colonial charm, and rich arts culture.

2. Oaxaca

This destination boasts an alluring indigenous history and deeply rooted traditions, encompassing everything from rich heritage foods to beautiful handicrafts.

3. Mexico City

Ranked among the top five, Mexico City has reemerged as a cosmopolitan ciudad teeming with chic hotels, elegant shops, and innovative restaurants, such as the award-winning St. Regis.

4. Cuzco

Once primarily known as the gateway to Machu Picchu, Cuzco features pre-Columbian temples, colonial buildings, and a unique shopping experience. As noted by reader Susan Bhati, “Everyone must travel to Cuzco; the buildings are a mix of Incan and European design, and its fun shopping.”

5. Antigua, Guatemala

Recognized for its rich history, Antigua secured the No. 5 spot among this year’s favorites.

Conclusion

Exploring these cities not only enriches travel experiences but also broadens perspectives through their unique cultures, exquisite cuisines, and welcoming atmospheres. Each destination reflects the beauty and diversity of Central and South America, making them a must-visit for avid travelers.

Buenos Aires - Argentina
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Pedro Del Castillo Square; Mendoza Argentina
Getty Images/Perspectives
Colombia, Bogota
John Coletti/Getty Images/AWL Images RM
Independence Square, Merida, Yucatan State, Mexico, North America
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Guadalajara's Main Square, the Plaza de Armas and La Merced church.
Luis Davilla/Getty Images
Mexico City
Fito Pardo/Getty Images


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